Slimming pens: variable effectiveness and challenges in treating obesity

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The treatment of obesity through injectable medications such as Ozempic and Wegovy has generated great expectations among patients and health professionals.

With promises of losing up to 22% of body weight, these medications have become a global phenomenon. However, recent studies indicate that around 20% of patients do not achieve expected results, raising questions about the effectiveness and challenges associated with these therapies.

Experts have pointed out that the variability in response to these medications is influenced by genetic, hormonal and behavioral factors. Despite high expectations, the experience of many patients has revealed the complexity of treating obesity in an efficient and personalized way.

The complexity of treating obesity

Obesity is a multifactorial condition, involving genetics, metabolism, eating behavior and environmental factors. The response to medications such as Ozempic and Wegovy depends on how each organism processes the active compounds. These medications, known as GLP-1 receptor agonists, mimic a hormone that regulates satiety and appetite. However, not all patients respond to these substances in the same way.

Initial clinical studies already indicated that between 10% and 15% of participants did not show the expected weight loss, losing less than 5% of their body weight. With the expanded use of these medications, this rate of non-responders increased to around 20%. This variation reflects the biological complexity of obesity, which cannot be reduced to a single solution.

Patient reports illustrate the challenges

The case of Danielle Griffin, a patient who has struggled with obesity since childhood, illustrates well the challenges faced by those seeking results with these therapies. After starting treatment with Wegovy, Griffin expected to lose about 30 kg. Despite following all medical advice and adapting her eating and exercise routine, she lost just 6 kg over the course of a year and a half. Although he saw benefits, such as reduced appetite and a lower risk of diabetes, Griffin described the experience as emotionally draining.

Like Griffin, many patients report frustration and disappointment when they realize that the results achieved are less than expected. Experts warn that it is essential to establish realistic expectations before starting treatment and emphasize that obesity is a chronic condition, which requires diverse and continuous strategies.

Factors influencing the effectiveness of medications

Variability in response to medications can be attributed to different factors. Studies highlight that pre-existing medical conditions, such as sleep apnea, and the use of medications such as antidepressants, steroids and contraceptives can limit the effectiveness of GLP-1 receptor agonists. Additionally, genetics plays an important role in how each person’s body responds to treatment.

Another relevant aspect is the impact of lifestyle habits on the success of therapy. Patients who do not incorporate changes in diet, physical activity and stress management may experience limited results. Experts reinforce that medications should be seen as support, and not as the only solution for weight loss.

Strategies to overcome the lack of response

When patients do not respond to medications as expected, doctors often adopt alternative strategies. Options include the use of other medications in the same class, which can activate additional hormonal pathways, or returning to older treatments, which may still be effective depending on the case.

In the case of Danielle Griffin, for example, the transition from Wegovy to Zepbound brought more promising results. After three months of using the new medication, she managed to lose about 7 pounds (approximately 3.2 kg). Although progress is slow, Griffin reported feeling more confident with this approach.

The role of medical monitoring and personalization of treatment

Personalizing treatment is essential to maximize results in the fight against obesity. Experts emphasize that a comprehensive approach, which takes individual factors into account, is essential to identify the best strategy for each patient. Furthermore, continuous medical monitoring allows treatment to be adjusted as necessary, increasing the chances of success.

Lifestyle changes are crucial components in treating obesity. Studies show that adopting a balanced diet, practicing regular physical exercise and managing stress can enhance the effects of medications. Furthermore, improving sleep quality and controlling emotional factors, such as anxiety, play an important role in the success of treatment.

The emotional challenges faced by patients

Obesity is a condition that goes beyond physical issues, profoundly impacting the emotional well-being of patients. The expectation of quick and significant results can generate frustration and discouragement when objectives are not achieved. To deal with these issues, many experts recommend psychological support as an integral part of treatment, helping patients develop a healthier relationship with their body and the weight loss process.

Future of obesity treatments

With advances in medicine and growing understanding of the mechanisms that regulate body weight, it is expected that new therapeutic options will be developed. However, experts emphasize that obesity must be approached holistically, combining medical interventions, behavioral changes and emotional support.

Practical tips to optimize results

1. Adopt a balanced diet, prioritizing foods rich in nutrients and avoiding ultra-processed products.
2. Practice physical activity regularly, choosing exercises that suit your fitness level and preferences.
3. Establish a consistent sleep routine, ensuring at least 7 to 8 hours of rest per night.
4. Manage stress through relaxation techniques such as meditation or yoga.
5. Maintain regular medical monitoring, adjusting treatment as necessary.

Advances and challenges in the treatment of obesity

Despite the limitations observed in some patients, medications such as Ozempic and Wegovy represent a significant advance in the treatment of obesity. However, it is essential that patients are educated on the possibilities and limitations of these therapies, adopting a realistic approach and committed to lasting lifestyle changes.

The search for effective and affordable solutions for treating obesity continues to be a priority for the medical community. Over time, it is expected that available therapies will become even more personalized, meeting patients’ individual needs and contributing to improved health and quality of life.