Innovative study highlights the link with the intestinal microbiome. Possible treatment involves B vitamins.
O gut microbiome could be the key to new treatments of the disease Parkinson.
A breakthrough highlights the link between the gut microbiome and Parkinson’s disease, pointing to a possible treatment involving B vitamins.
Researchers have identified specific gut bacteria associated with reduced levels of riboflavin (vitamin B2) and biotin (vitamin B7) in Parkinson’s patients.
Parkinson’s, a neurodegenerative disease that affects about 10 million people worldwide, often begins with subtle symptoms such as constipation and sleep problems decades before progressing to severe motor disability and dementia.
Previous research has already linked Parkinson’s to changes in the gut microbiome long before other symptoms appear.
In this study, by analyzing fecal samples from 94 Parkinson’s patients and 73 controls in Japan, researchers found consistent patterns of gut bacteria associated with altered synthesis of B vitamins in several countries, including China, Germany and the USA.
This deficiency affects the production of short-chain fatty acids (SCFAs) e polyamine, essential molecules for maintaining a healthy intestinal mucus layer.
Weakened intestinal barriers can expose the nervous system to environmental toxins such as pesticides e herbicides, which are suspected of triggering excessive production of α-synuclein fibrils.
These molecules accumulate in brain cells that produce dopamine, contributing to Parkinson’s symptoms.
Previous studies suggest that high doses of riboflavin can help restore motor function when combined with dietary changes, such as avoiding red meat.
The team of researchers who supplemented riboflavina (vitamina B2) e biotin (B7) may help prevent damage in some patients, particularly those with intestinal dysbiosis.
Future approaches may include gut microbiome analysis and targeted supplementation for individuals with specific deficiencies.
But this connection already suggests a simple and unexpected treatmentresume o .
Although more research is needed, the results highlight the importance of maintaining gut health and reducing environmental toxins as potential strategies for combating Parkinson’s disease.
