Anxiety and its disorders are becoming an increasingly pressing problem in the modern world. Scientists estimate that about 4% of the world’s population is suffering from anxiety disorders. While traditional treatment methods help many people reduce anxiety, new studies reveal an interesting relationship between microbiome and anxiety, which could open the door to new, safer treatments.
Challenges of current anxiety treatment methods
Currently, anxiety disorders are usually treated in a complex way, combining psychotherapy, lifestyle changes and medication. However, current treatment methods are not always effective enough-studies show that only 60-85% of patients respond well to treatment. In addition, treatment is often long and expensive, and medication can cause unpleasant side effects.
Particularly problematic is the widely used anti -anxiety medicines – benzodiazepines and SSRI (selective serotonin reuptake inhibitors). Benzodiazepines can lead to addiction, drowsiness, cognitive impairment and memory problems. SSRI, while considered safer, also has its own disadvantages – they can cause weight gain, sexual dysfunction and digestive problems. Termination of the use of these drugs can be particularly complex.
New study: the role of intestinal microbiome to reduce anxiety
A recent study published by Embbo Molecular Medicine has opened new prospects for the treatment of anxiety. Scientists identified a specific microbial metabolite in the intestinal microbiome, which helps regulate anxiety -related brain activity.
During the study, scientists worked with a special mouse model that removed the intestinal microbiome. While observing the behavior of these mice, they noticed a significantly increased level of anxiety. A deeper analysis has revealed increased activity in the Basolateral Amigdala, the brain area responsible for emotion regulation, especially fear and anxiety.
Particularly interesting is that the treatment with indols – natural compounds produced by intestinal bacteria – has significantly reduced the symptoms of anxiety. This discovery reveals a potentially new, more natural way to fight anxiety.
Although scientists have long been aware of the intestinal and brain connection, this understanding has now expanded into a complex axis of intestinal-stragey-mikrobiomo. This means that any change in one system can have a significant impact on others. For example, changes in brain activity can affect bowel function, which in turn changes the microbiome. Microbiomo changes again can affect brain activity by closing this complex circle of communications.
Practical recommendations
While researchers are continuing research, we can already start paying more attention to bowel health. A balanced diet rich in fiber and fermented products can help maintain a healthy intestinal microbiome. Regular physical activity and stress management techniques can also have a positive impact on both intestinal and brain health.
Scientific progress in intestinal microbiome research opens up new opportunities for the treatment of anxiety disorders. Although detailed clinical trials with people are still needed, we already see that intestinal health can be the key to better mental well -being. This promotes a holistic approach to anxiety treatment, where focus is not only on the relief of symptoms but also for the deep interactions of the body’s systems.
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