Qian, N., Weinstein, J.A. Spatial
It is already possible to “photograph” each gene of a living being: all thanks to DNA, which after all has very useful paparazzi skills. It’s a “level of biology no one has seen before.”
The new technology developed by the University of Chicago captures both identity and the location of genetic material.
Innovation works through the Individual DNA or ARN and the tracking interaction between neighboring brandscounts a.
These interactions make us true three-dimensional maps of entire organisms, for example, of unlucky fish embryos, used for testing by scientists- The images are captured from the inside out.
O Published this Thursday in Nature He used the unlucky fish embryo because this is very common to study the nervous system. “It’s a Biology level that no one has ever seen before“Comments the author Joshua Weinstein.” Being able to have this kind of vision of nature from a specimen is stimulating. “
In this system are added to the small cells of DNA sequence called unique molecular identifiers (UMIS). These bind to DNA and Arn molecules and begin to make copies of themselves.
The author compares this system to the location of an IP from a mobile phone. “We can do this with mobile phones and people, why not do it with molecules and cells?“ This It becomes the idea of the imaging inside out. Instead of depending on an optical device to illuminate, we can use biochemistry and DNA to form a massive network between molecules and coding their proximities.
This innovation can have future applications in the Tumor Mappingfor example, and in the perception of its interaction with the environment. A tumor generates mutations, and through this method these genetic mechanisms can be improved.
“This is the fundamental basis for being able to have truly complete information on the Set of unique cells non -lymphatic system Or in tumor tissue, ”said Weinstein.” There is still a large gap in technology that allows us to understand idiosyncratic tissue, and that’s what we are trying to fill here. “
