A pill that works differently from the popular Ozepic can help people lose weight without losing their appetite: it is able to burn energy and therefore fat.
O Ozempic and other medicines with GLP-1 reduce food intake, stimulating satiety.
They work in the brain to promote satiety and intestine to slow food movement through the stomach, helping people feel satisfied for longer.
As a result, people who take these medicines lose weight because they eat less.
A new drug now presented can however be able to burn energy and therefore fat, without reducing appetite.
In a phase I described today in the journal Nature Metabolism, the drug led to statistically significant weight loss in participants after two weeks.
So -called Verythe drug is derived from salicylate, compound used in the production of aspirin. Developed by Eolo Pharmafrom Montevideo, Uruguay, activates a way called creatine -dependent thermogenesis.
Creatine is perhaps better known as a nutritional supplement taken after exercise to help build muscle massbut the compound also occurs Naturally in the human body And it is important for energy production.
“ Creatine has good effects No metabolism, ”he says Carlos Escandeco -founder and scientific director of EOLO. In the 1970s, researchers found that the cold rats consumed too much creatine.
According to, only a decade is that a Harvard team found that creatine is used in adipose fabric during exposure to cold to generate heat. The process of burning energy and heat generation to maintain a stable internal temperature is known as thermogenesis.
A thermogenesis It is dependent on creatine, being related to how it decomposes it, particularly in fat cells, contributes to heat and energy production.
“What we find is that our compound stimulates this cop production of creatine dependent,” says Escande.
In the first part of the study, Eolo Pharma scientists selected at random 17 individuals healthy weight to receive a placebo or a single pill of sana at a low, medium or high dose. In all doses, the drug was well tolerated, without serious side effects.
In the second part of the study, they tested the drug in 24 participants with obesity for 15 days. Volunteers were randomly divided into three groups to receive a placebo or a low, medium or high dose of Sana twice a day throughout the study.
Each group had six people taking the medicine and two to take placebo. During the study period, participants remained in a clinical unit where they received rich carbohydrate meals.
At the end of the two weeks, the participants who took the highest dose of Sana presented a weight loss of about 3%, Comparable to weight loss observed in people who took Ozepic and Wegovy during the same period of treatment.
They were also asked to fulfill a questionnaire about appetite and satiety, and None reported a decrease in appetite or satiety.
Although injecting GLP-1 drugs are incredibly effective in stimulating weight loss, present some disadvantagescan provoke gastrointestinal side effects and muscle loss.
Treatments with these drugs also have a high cost, which can reach $ 1,000 a month or more in the US.
Pharmaceutical companies are interested in developing anti-overall compresses due to their relatively low manufacturing cost Compared to the injectables, and the fact that some patients prefer to take a tablet.
“There is still an unattended clinical need, and that’s where Eolo wants to help,” he says María Sink competitionsCEO of the company. Eolo did not properly want to make a pill to lose weight.
Company researchers were initially trying to develop a medicine for combat inflammationespecially the type that occurs in obesity and type 2 diabetes.
But when they tested the experimental drug in mice, it not only improved inflammation, but also led to a Body weight reduction of the mice, which followed a Diet rich in fat.
The researchers then conducted experiences with the duration of nine months and found that the mice They eventually returned to the initial weighteven keeping the same fat -rich diet.
In mice, Sana also preserved lean muscle mass. Magnetic resonance imaging show that the mice treated with Sana had a higher percentage of lean body mass compared to the controls, despite the substantial loss of fat.
