It is all about Kupffer’s cell – the “maestro” of liver cells. Fat is very harmful to the liver, new study reveals.
that children born of overweight mothers often face metabolic challenges later in life. But now a new one published in Nature This month proves that liver damage can be irreparable.
dog. A certain type of immune cell in the liver, the cell of Kupfferbegins to give different instructions when the mother is considered obese. And the rest of the liver obeys, explains the.
“But these Kupffer cells also act as conductors,” says Elvira Mass of the Limes Institute of the University of Bona. “They instruct the liver cells around them about what to do. Thus, they help ensure that the liver, as a central organ of metabolism, correctly performs its many functions.”
But in the offspring of overweight mothers, these instructions change. Kupffer cells tell liver cells to absorb fat. Fat they don’t need. Fat that ends up causing disease.
“We were able to demonstrate that the descent of obese mothers often developed fat liver shortly after birth,” said study co-author Hao Huang of the University of Bona. “And this even happened when young animals were fed with a completely normal diet.”
“It is increasingly clear than many diseases in humans They start at a very early stage of development“, Mass.” Our study is one of the few that explains in detail how this initial programming can happen. “
It seems like a discovery that does not bring good news, but it can actually open several doors: if researchers find ways of reprogramming or restarting kupffer cells, they can cut the greasy liver disease at the root.
