Aging changes the body’s responses to infections while the flu becomes particularly dangerous older to the people. Recent research reveals that the main role in the process is the protein Apolipoprotein D. Understanding how this mechanism works can help to better protect seniors and reduce the risk of complications.
Older people’s immune system and flu
Researchers from China and the United Kingdom have found that in the lungs of the elderly, the amount of apolipoprotein D increases significantly in the lungs. This is involved in lipid metabolism and inflammatory processes, but excessive levels inhibit the body’s antivirus protection. This makes the virus more easily multiplied and the lung tissues suffer serious damage.
As apolipoprotein d disturbs protection
Analysis with human donor fabrics and mice experiments showed that apolipoprotein D violates mitochondrial activity – cellular “most powerful centers”. Mitochondria are essential for the production of interferons, which are the main defense mechanism against viruses. The lack of interferons results in a more severe course, and the body of the elderly is particularly vulnerable.
Why Aging Increases Risk
This discovery helps explain why age is one of the most important risk factors for mortality from influenza. In the elderly, this effect of protein is stronger and is more likely to experience severe complications.
Prospects for future treatment
Researchers say that blocking apolipoprotein D may lead to new drug development opportunities to reduce the likelihood of complications in elderly patients. Such drugs could be extremely important in view of the global trend of the aging population.
Research on this protein can become an important step to ensure a safer life for seniors and reduce the number of hospitalizations and influenza deaths.
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