New study revealed a unique way to simply predict how much time does a person remain. Scientists claim that this is possible thanks to the spray from the mouth that Can estimate the risk of death of a patient using cells found in the mouth. , experts have confirmed that this method will try to improve.
The risk of death can already be detected by face
People get older at a different pace but it is known to be An unfavorable lifestyle, stress, smoking, alcohol or poor lifestyle can speed up this process. Since such influences literally pushed into our genome in the form of epigenetic signs, Scientists tried to quantify molecular aging by characterizing these epigenomas in certain places of the body.
Over the past decade scientists have developed several so -called epigenetic clockswhich are calibrated according to chronological age and lifestyle factors for a large number of subjects. However, most of them are focused on the methylation of DNA in blood cells, which makes it difficult to take samples and at the same time it is stressful for the patient.
But American scientists have recently managed to develop a test called Cheekage who Works with data on methylation in lightly taken cells from the inside of the face. can do accurately predict the risk of death, even if epigenetic data from other tissue is used.
The risks will be able to detect such a simple test.
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They practiced it on a large number of subjects
As the first author of the study by Dr. Maxim Shokhirev, cheekage was developed correlation of the proportion of methylation to approximately 200,000 sites with total health and lifestyle scores that reflect the expected differences in physiological aging. Together with colleagues Shokhirev, he used statistical programming to see how well their test predicts death.
Later it was tried under Lothian Birth Cohorts (LBC) of Edinburg University, which watched the lives of 1,513 men and women born in 1921 and 1936. One of the goals was to link differences in cognitive aging with lifestyle, psychosocial factors and biomedical and genetic data of the brain. “Cheekage significantly overcomes the first -generation epigenetic clockswhich were trained using blood data containing data, “added Dr. Shokhirev.
According to scientists, these epigenetic clocks are mainly trained on facial cells. “That means A simple non -invasive swab from the face can be a valuable alternative for studying and monitoring biology of aging“they noted.
Scientists also examined in more detail those methylation sites that were most associated with mortality. Found that The genes in their surroundings are potential candidates to influence life expectancy or risk -related risk. In particular, they pointed out PDZRN4 genes (tumor suppressor) and ALPK2, which is involved in animal health. “It would be interesting to find out if genes such as Alpk2 affect life expectancy“said Dr. Adiv Johnson of Tally Health.
According to Johnson, however, it will be essential for scientists to carry out further studies to find out What other context in addition to mortality for all causes can be captured using a cheekage test.
