One of the most worrisome is canine dementia (CCD), also known as cognitive dysfunction syndrome (CDS), a neurodegenerative disease similar to Alzheimer’s disease in humans, writes Science Alert.
Canine dementia (CCD) begins slowly and progressively, and the initial signs can easily be overlooked by owners, being confused with “normal aging” of the dog. Specialists warn, however, that early identification of the symptoms of canine dementia (CCD) can make a difference in terms of the animal’s quality of life, inform Noi.md with reference to .
The clinical signs of canine dementia (CCD) are non-specific but recurrent. Vets use the acronym DISHA(A) to help owners recognize:
-
Disorientation in familiar environments
-
Changes in social interactions
-
Changes in the sleep-wake cycle
-
House-soiling
-
Changes in activity level
-
Anxiety and aggression (optional)
A dog with canine dementia (CCD) may forget where the water bowl is, become apathetic or overly dependent, bark for no reason, or walk around restlessly at night.
Currently, there is no standardized test or clear biomarker for the diagnosis of canine dementia (CCD). The assessment is based on behavioral scales such as CADES, CCAS or CCDR. Recent studies show that up to 60-66% of dogs over seven years of age show various forms of cognitive decline.
The only FDA-approved drug for canine dementia (CCD) is selegiline, but its effectiveness remains questionable. For this reason, researchers are exploring alternatives such as cognitive exercises, mental training, environmental modifications, and supplements, including melatonin.
Research shows that the brains of dogs affected by canine dementia (CCD) show accumulations of amyloid plaques and proteins similar to those seen in Alzheimer’s disease. For this reason, dogs are considered valuable biological models for the study of human dementia, more relevant than laboratory animals, because they live in the same environment as humans.
Projects like the Dog Aging Project in the US aim not only to extend the lives of dogs, but also to improve human health through these discoveries.
